Reaction Details Report a problem with these data
Target
Acid-sensing ion channel 3
Ligand
BDBM50250132
Substrate
n/a
Meas. Tech.
ChEBML_1680987
IC50
891251±n/a nM
Citation
 Lynagh, T; Romero-Rojo, JL; Lund, C; Pless, SA Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen. J Med Chem 60:8192-8200 (2017) [PubMed]  Article 
Target
Name:
Acid-sensing ion channel 3
Synonyms:
ASIC3_RAT | Accn3 | Amiloride-sensitive cation channel 3 | Asic3 | Drasic
Type:
PROTEIN
Mol. Mass.:
59229.99
Organism:
Rattus norvegicus
Description:
ChEMBL_938637
Residue:
533
Sequence:
MKPRSGLEEAQRRQASDIRVFASSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQVAERVRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYLRALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQPCGPENFTVIFTRMGQCYTFNSGAHGAELLTTPKGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHSQDEPPAIDQLGFGAAPGHQTFVSCQQQQLSFLPPPWGDCNTASLDPDDFDPEPSDPLGSPRPRPSPPYSLIGCRLACESRYVARKCGCRMMHMPGNSPVCSPQQYKDCASPALDAMLRKDTCVCPNPCATTRYAKELSMVRIPSRASARYLARKYNRSESYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFIGASLLTILEILDYLCEVFQDRVLGYFWNRRSAQKRSGNTLLQEELNGHRTHVPHLSLGPRPPTTPCAVTKTLSASHRTCYLVTRL
  
Inhibitor
Name:
BDBM50250132
Synonyms:
CHEMBL4080879
Type:
Small organic molecule
Emp. Form.:
C12H15FO2
Mol. Mass.:
210.2447
SMILES:
CC(C)Cc1ccc(cc1)C(F)C(O)=O
Structure:
Search PDB for entries with ligand similarity: