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Target
Heme ligase
Ligand
BDBM50250134
Substrate
n/a
Meas. Tech.
ChEBML_1681013
Kd
2960±n/a nM
Citation
 Gupta, P; Mehrotra, S; Sharma, A; Chugh, M; Pandey, R; Kaushik, A; Khurana, S; Srivastava, N; Srivastava, T; Deshmukh, A; Panda, A; Aggarwal, P; Bhavesh, NS; Bhatnagar, RK; Mohmmed, A; Gupta, D; Malhotra, P Exploring Heme and Hemoglobin Binding Regions of Plasmodium Heme Detoxification Protein for New Antimalarial Discovery. J Med Chem 60:8298-8308 (2017) [PubMed]  Article 
Target
Name:
Heme ligase
Synonyms:
4.99.1.8 | HDP | HDP_PLAF7
Type:
PROTEIN
Mol. Mass.:
24349.37
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_117325
Residue:
205
Sequence:
MKNRFYYNLIIKRLYTRSGGLRKPQKVTNDPESINRKVYWCFEHKPVKRTIINLIYSHNELKIFSNLLNHPTVGSSLIHELSLDGPYTAFFPSNEAMQLINIESFNKLYNDENKLSEFVLNHVTKEYWLYRDLYGSSYQPWLMYNEKREAPEKLRNLLNNDLIVKIEGEFKHCNHSIYLNGSKIIRPNMKCHNGVVHIVDKPIIF
  
Inhibitor
Name:
BDBM50250134
Synonyms:
CHEMBL4068384
Type:
Small organic molecule
Emp. Form.:
C21H21F3N2
Mol. Mass.:
358.4
SMILES:
FC(F)(F)c1cccc(c1)N1CCN(CC1)C1=Cc2ccccc2CC1 |t:18|
Structure:
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