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Target
Sodium- and chloride-dependent GABA transporter 2
Ligand
BDBM50203383
Substrate
n/a
Meas. Tech.
ChEBML_1681421
Ki
23000±n/a nM
Citation
 Jørgensen, L; Al-Khawaja, A; Kickinger, S; Vogensen, SB; Skovgaard-Petersen, J; Rosenthal, E; Borkar, N; Löffler, R; Madsen, KK; Bräuner-Osborne, H; Schousboe, A; Ecker, GF; Wellendorph, P; Clausen, RP Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/?-Aminobutyric Acid Transporter 1 (BGT1). J Med Chem 60:8834-8846 (2017) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 2
Synonyms:
GABA transporter 2 | GAT2 | S6A13_HUMAN | SLC6A13
Type:
PROTEIN
Mol. Mass.:
68012.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1454197
Residue:
602
Sequence:
MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTELESHC
  
Inhibitor
Name:
BDBM50203383
Synonyms:
CHEMBL228972 | N-(1-benzylpiperidin-4-yl)-2-naphthamide | N-(1-benzylpiperidine-4-yl)-2-naphthamide
Type:
Small organic molecule
Emp. Form.:
C23H24N2O
Mol. Mass.:
344.4495
SMILES:
O=C(NC1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: