Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50005846
Substrate
n/a
Meas. Tech.
ChEMBL_139354 (CHEMBL752402)
Ki
30000±n/a nM
Citation
 Nordvall, G; Sundquist, S; Glas, G; Gogoll, A; Nilvebrant, L; Hacksell, U Analogues of the muscarinic agent 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]: synthesis and pharmacology. J Med Chem 35:1541-50 (1992) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50005846
Synonyms:
2',2'-dimethylspiro[4-azabicyclo[2.2.2]octane-2,4'-[1,3]dioxolane] | CHEMBL39922
Type:
Small organic molecule
Emp. Form.:
C11H19NO2
Mol. Mass.:
197.2741
SMILES:
CC1(C)OCC2(CN3CCC2CC3)O1 |(16.5,-.14,;15.01,-.56,;14.22,.79,;15.79,-1.89,;14.76,-3.03,;13.35,-2.41,;13.35,-3.95,;12.01,-4.72,;10.68,-3.95,;10.68,-2.41,;12.01,-1.64,;11.49,-2.82,;12.61,-3.47,;13.51,-.88,)|
Structure:
Search PDB for entries with ligand similarity: