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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50005843
Substrate
n/a
Meas. Tech.
ChEMBL_138135 (CHEMBL747394)
Ki
20000±n/a nM
Citation
 Nordvall, G; Sundquist, S; Glas, G; Gogoll, A; Nilvebrant, L; Hacksell, U Analogues of the muscarinic agent 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]: synthesis and pharmacology. J Med Chem 35:1541-50 (1992) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50005843
Synonyms:
(2R,5'R)-5'-methyldihydro-3'H-spiro[4-azabicyclo[2.2.2]octane-2,2'-furan] | CHEMBL39843
Type:
Small organic molecule
Emp. Form.:
C11H19NO
Mol. Mass.:
181.2747
SMILES:
C[C@@H]1CCC2(CN3CCC2CC3)O1 |wD:1.0,(8.15,-1.22,;7.52,-2.61,;8.29,-3.96,;7.26,-5.1,;5.85,-4.47,;5.85,-6.01,;4.5,-6.78,;3.19,-6.01,;3.19,-4.47,;4.5,-3.7,;3.99,-4.89,;5.11,-5.53,;6.01,-2.93,)|
Structure:
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