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Target
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Ligand
BDBM50252338
Substrate
n/a
Meas. Tech.
ChEBML_1684606
IC50
9200±n/a nM
Citation
 Zhou, D; Springer, MZ; Xu, D; Liu, D; Hudmon, A; Macleod, KF; Meroueh, SO Small molecules inhibit STAT3 activation, autophagy, and cancer cell anchorage-independent growth. Bioorg Med Chem 25:2995-3005 (2017) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Synonyms:
2.7.11.17 | CAMK | CAMK-II | CAMK2G | CAMKG | CaM kinase II | CaM kinase II gamma | CaM kinase II subunit gamma | CaMK-II subunit gamma | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMKllg) | KCC2G_HUMAN
Type:
Protein
Mol. Mass.:
62621.56
Organism:
Homo sapiens (Human)
Description:
Q13555
Residue:
558
Sequence:
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKGRVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
  
Inhibitor
Name:
BDBM50252338
Synonyms:
CHEMBL4090364
Type:
Small organic molecule
Emp. Form.:
C25H30Cl3N5
Mol. Mass.:
506.898
SMILES:
CCN(CC)CCCC(C)Nc1nc(\C=C\c2c(Cl)cc(Cl)cc2Cl)nc2ccc(N)cc12
Structure:
Search PDB for entries with ligand similarity: