Reaction Details Report a problem with these data
Target
Carbonic anhydrase-related protein 11
Ligand
BDBM50253847
Substrate
n/a
Meas. Tech.
ChEBML_1685888
Ki
4.5±n/a nM
Citation
 Karal?, N; Akdemir, A; Gökta?, F; Eraslan Elma, P; Angeli, A; K?z?l?rmak, M; Supuran, CT Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases. Bioorg Med Chem 25:3714-3718 (2017) [PubMed]  Article 
Target
Name:
Carbonic anhydrase-related protein 11
Synonyms:
CA-RP II | CA-RP XI | CA-XI | CA11 | CAH11_HUMAN | CARP XI | CARP-2 | CARP2 | CARP2 | Carbonic anhydrase-related protein 11 | Carbonic anhydrase-related protein 2
Type:
PROTEIN
Mol. Mass.:
36252.43
Organism:
Homo sapiens
Description:
ChEMBL_12954
Residue:
328
Sequence:
MGAAARLSAPRALVLWAALGAAAHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWSLCAVGKRQSPVDVELKRVLYDPFLPPLRLSTGGEKLRGTLYNTGRHVSFLPAPRPVVNVSGGPLLYSHRLSELRLLFGARDGAGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNGLAILSLFVNVASTSNPFLSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGSLSTPPCSETVTWILIDRALNITSLQMHSLRLLSQNPPSQIFQSLSGNSRPLQPLAHRALRGNRDPRHPERRCRGPNYRLHVDGVPHGR
  
Inhibitor
Name:
BDBM50253847
Synonyms:
CHEMBL4081547
Type:
Small organic molecule
Emp. Form.:
C15H12FN5O3S2
Mol. Mass.:
393.416
SMILES:
NS(=O)(=O)c1ccc(NC(=S)N\N=C2/C(=O)Nc3ccc(F)cc23)cc1
Structure:
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