Reaction Details Report a problem with these data
Target
Growth/differentiation factor 8
Ligand
BDBM50206029
Substrate
n/a
Meas. Tech.
ChEBML_1686452
IC50
1190±n/a nM
Citation
Takayama, K; Rentier, C; Asari, T; Nakamura, A; Saga, Y; Shimada, T; Nirasawa, K; Sasaki, E; Muguruma, K; Taguchi, A; Taniguchi, A; Negishi, Y; Hayashi, Y Development of Potent Myostatin Inhibitory Peptides through Hydrophobic Residue-Directed Structural Modification. ACS Med Chem Lett 8:751-756 (2017) [PubMed] Article
More Info.:
Target
Name:
Growth/differentiation factor 8
Synonyms:
GDF-8 | GDF8 | GDF8_HUMAN | Growth/differentiation factor 8 | MSTN | Myostatin
Type:
PROTEIN
Mol. Mass.:
42750.72
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109584
Residue:
375
Sequence:
MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
Inhibitor
Name:
BDBM50206029
Synonyms:
CHEMBL3892004
Type:
Small organic molecule
Emp. Form.:
C131H220N40O33
Mol. Mass.:
2883.3967
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)COc1ccc2ccccc2c1)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O |r|