Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 6
Ligand
BDBM50255479
Substrate
n/a
Meas. Tech.
ChEMBL_1687096 (CHEMBL4037575)
EC50
>10000±n/a nM
Citation
 Lu, H; Yang, T; Xu, Z; Lin, X; Ding, Q; Zhang, Y; Cai, X; Dong, K; Gong, S; Zhang, W; Patel, M; Copley, RCB; Xiang, J; Guan, X; Wren, P; Ren, F Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem 61:2518-2532 (2018) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 6
Synonyms:
BONZO | C-X-C chemokine receptor type 6 | CD_antigen=CD186 | CDw186 | CXC-R6 | CXCR-6 | CXCR6 | CXCR6_HUMAN | G-protein coupled receptor STRL33 | G-protein coupled receptor bonzo | STRL33 | TYMSTR
Type:
PROTEIN
Mol. Mass.:
39289.05
Organism:
Homo sapiens
Description:
ChEMBL_102648
Residue:
342
Sequence:
MAEHDYHEDYGFSSFNDSSQEEHQDFLQFSKVFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNFWKLVKDIGCLPYLGVSHQWKSSEDNSKTFSASHNVEATSMFQL
  
Inhibitor
Name:
BDBM50255479
Synonyms:
CHEMBL4067429
Type:
Small organic molecule
Emp. Form.:
C18H23ClN2O5S
Mol. Mass.:
414.904
SMILES:
CC1=CCC[C@H]1NC(=O)Nc1ccc(Cl)c(c1O)S(=O)(=O)[C@@]1(C)CCOC1 |r,t:1|
Structure:
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