Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50256769
Substrate
n/a
Meas. Tech.
ChEBML_1688180
Ki
8.4±n/a nM
Citation
 Mohamed, MA; Abdel-Aziz, AA; Sakr, HM; El-Azab, AS; Bua, S; Supuran, CT Synthesis and human/bacterial carbonic anhydrase inhibition with a series of sulfonamides incorporating phthalimido moieties. Bioorg Med Chem 25:2524-2529 (2017) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50256769
Synonyms:
CHEMBL4094824
Type:
Small organic molecule
Emp. Form.:
C24H18IN3O7S
Mol. Mass.:
619.385
SMILES:
NS(=O)(=O)c1ccc(CCN2C(=O)c3ccc(cc3C2=O)C(=O)Nc2ccc(I)cc2C(O)=O)cc1
Structure:
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