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Target
Nucleoprotein
Ligand
BDBM50256886
Substrate
n/a
Meas. Tech.
ChEBML_1688494
IC50
2.0±n/a nM
Citation
 Fordyce, EAF; Brookes, DW; Lise-Ciana, C; Coates, MS; Hunt, SF; Ito, K; King-Underwood, J; Onions, ST; Parra, GF; Rapeport, G; Sherbukhin, V; Stockwell, JA; Strong, P; Thomas, JC; Murray, J Discovery of novel benzothienoazepine derivatives as potent inhibitors of respiratory syncytial virus. Bioorg Med Chem Lett 27:2201-2206 (2017) [PubMed]  Article 
Target
Name:
Nucleoprotein
Synonyms:
N | NCAP_HRSVA | Nucleocapsid protein | Protein N
Type:
PROTEIN
Mol. Mass.:
43455.45
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
ChEMBL_117398
Residue:
391
Sequence:
MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDSIDTPNYDVQKHINKLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILRDAGYHVKANGVDVTTHRQDINGKEMKFEVLTLASLTTEIQINIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCIAALVITKLAAGDRSGLTAVIRRANNVLKNEMKRYKGLLPKDIANSFYEVFEKHPHFIDVFVHFGIAQSSTRGGSRVEGIFAGLFMNAYGAGQVMLRWGVLAKSVKNIMLGHASVQAEMEQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPHFSSVVLGNAAGLGIMGEYRGTPRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKHQLNPKDNDVEL
  
Inhibitor
Name:
BDBM50256886
Synonyms:
CHEMBL4091425
Type:
Small organic molecule
Emp. Form.:
C40H35FN6O3S
Mol. Mass.:
698.808
SMILES:
Cc1cnc(N2CC3(C2)CCOCC3)c(c1)C(=O)Nc1ccc(cc1)C(=O)N1CCc2cc(sc2-c2ccccc12)-c1nc2cccc(F)c2[nH]1
Structure:
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