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Target
Rhodopsin kinase GRK7
Ligand
BDBM50257328
Substrate
n/a
Meas. Tech.
ChEBML_1689812
IC50
8800±n/a nM
Citation
 Okawa, T; Aramaki, Y; Yamamoto, M; Kobayashi, T; Fukumoto, S; Toyoda, Y; Henta, T; Hata, A; Ikeda, S; Kaneko, M; Hoffman, ID; Sang, BC; Zou, H; Kawamoto, T Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure. J Med Chem 60:6942-6990 (2017) [PubMed]  Article 
Target
Name:
Rhodopsin kinase GRK7
Synonyms:
G protein-coupled receptor kinase 7 | GPRK7 | GRK7 | GRK7_HUMAN
Type:
PROTEIN
Mol. Mass.:
62210.84
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774199
Residue:
553
Sequence:
MVDMGALDNLIANTAYLQARKPSDCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPFLSQAVATKCQAATTEEERVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSREKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELNDPNRPTGCEEGNSSKSGVCLLL
  
Inhibitor
Name:
BDBM50257328
Synonyms:
CHEMBL4082775
Type:
Small organic molecule
Emp. Form.:
C22H20N6O
Mol. Mass.:
384.4338
SMILES:
O=C(NCc1ccccc1)c1cccc(NCc2nc(n[nH]2)-c2ccncc2)c1
Structure:
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