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Target
Metabotropic glutamate receptor 2
Ligand
BDBM50257551
Substrate
n/a
Meas. Tech.
ChEMBL_1689940 (CHEMBL4040510)
Ki
1.9±n/a nM
Citation
 Doornbos, MLJ; Cid, JM; Haubrich, J; Nunes, A; van de Sande, JW; Vermond, SC; Mulder-Krieger, T; Trabanco, AA; Ahnaou, A; Drinkenburg, WH; Lavreysen, H; Heitman, LH; IJzerman, AP; Tresadern, G Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2. J Med Chem 60:6704-6720 (2017) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 2
Synonyms:
GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2
Type:
Enzyme
Mol. Mass.:
95584.88
Organism:
Homo sapiens (Human)
Description:
Q14416
Residue:
872
Sequence:
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
  
Inhibitor
Name:
BDBM50257551
Synonyms:
CHEMBL4077609
Type:
Small organic molecule
Emp. Form.:
C23H23ClF3N3O2
Mol. Mass.:
465.896
SMILES:
O[C@H]1CC[C@@H](CC1)Oc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F |r,wU:4.7,wD:1.0,(54.3,-43.98,;54.3,-42.44,;55.64,-41.67,;55.65,-40.12,;54.31,-39.36,;52.98,-40.12,;52.97,-41.66,;54.32,-37.83,;55.65,-37.06,;56.98,-37.83,;58.32,-37.06,;58.32,-35.5,;56.98,-34.74,;55.65,-35.51,;54.32,-34.74,;59.64,-34.73,;60.98,-35.5,;62.31,-34.73,;62.31,-33.19,;63.45,-32.15,;64.95,-32.46,;65.44,-33.93,;65.13,-35.43,;66.59,-34.95,;62.81,-30.75,;61.29,-30.91,;60.97,-32.42,;59.63,-33.19,;58.3,-32.43,;58.29,-30.89,;56.97,-33.2,;56.95,-31.65,)|
Structure:
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