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Target
Heat shock 70 kDa protein 1A
Ligand
BDBM50260460
Substrate
n/a
Meas. Tech.
ChEBML_1693902
IC50
>100000±n/a nM
Citation
 Tillotson, J; Kedzior, M; Guimarães, L; Ross, AB; Peters, TL; Ambrose, AJ; Schmidlin, CJ; Zhang, DD; Costa-Lotufo, LV; Rodríguez, AD; Schatz, JH; Chapman, E ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A. Bioorg Med Chem Lett 27:4082-4085 (2017) [PubMed]  Article 
Target
Name:
Heat shock 70 kDa protein 1A
Synonyms:
HS71A_HUMAN | HSP70-1/HSP70-2 | HSP70.1 | HSP72 | HSPA1 | HSPA1A | HSX70 | Heat Shock 70kDa Protein 1 | Heat shock 70 kDa protein 1A/1B | Hsp70
Type:
Chaperone
Mol. Mass.:
70043.82
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
641
Sequence:
MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
  
Inhibitor
Name:
BDBM50260460
Synonyms:
ELISABATIN A
Type:
Small organic molecule
Emp. Form.:
C20H22O3
Mol. Mass.:
310.3869
SMILES:
[#6]-[#6@H]-1-[#6]-[#6@@H](\[#6]=[#6](\[#6])-[#6])-[#6]-2=[#6](-[#6])-[#6](=O)-[#6](=O)-c3c(-[#6])cc(-[#8])c-1c-23 |r,c:8|
Structure:
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