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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50261831
Substrate
n/a
Meas. Tech.
ChEBML_1696472
IC50
8.0±n/a nM
Citation
 Barberis, C; Moorcroft, N; Pribish, J; Tserlin, E; Gross, A; Czekaj, M; Barrague, M; Erdman, P; Majid, T; Batchelor, J; Levit, M; Hebert, A; Shen, L; Moreno-Mazza, S; Wang, A Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification - Part II. Bioorg Med Chem Lett 27:4735-4740 (2017) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50261831
Synonyms:
CHEMBL4065094
Type:
Small organic molecule
Emp. Form.:
C14H14Cl2IN3O2
Mol. Mass.:
454.09
SMILES:
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCC(O)CC3)c2n1 |(47.27,-30.19,;47.27,-28.65,;45.94,-27.88,;48.61,-27.88,;48.61,-26.34,;49.94,-25.57,;49.93,-24.03,;51.27,-26.33,;52.74,-25.85,;53.2,-24.38,;53.65,-27.09,;55.19,-27.08,;52.75,-28.34,;53.24,-29.8,;52.21,-30.94,;52.69,-32.4,;54.19,-32.72,;54.67,-34.18,;55.22,-31.57,;54.74,-30.1,;51.28,-27.87,;49.94,-28.65,)|
Structure:
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