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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50261866
Substrate
n/a
Meas. Tech.
ChEBML_1696472
IC50
3.0±n/a nM
Citation
 Barberis, C; Moorcroft, N; Pribish, J; Tserlin, E; Gross, A; Czekaj, M; Barrague, M; Erdman, P; Majid, T; Batchelor, J; Levit, M; Hebert, A; Shen, L; Moreno-Mazza, S; Wang, A Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification - Part II. Bioorg Med Chem Lett 27:4735-4740 (2017) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50261866
Synonyms:
CHEMBL4087517
Type:
Small organic molecule
Emp. Form.:
C15H17Cl2IN4O
Mol. Mass.:
467.132
SMILES:
NCC1CCC(CC1)n1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O |(25.89,-37.44,;26.91,-36.3,;26.43,-34.83,;24.93,-34.51,;24.45,-33.06,;25.48,-31.92,;26.98,-32.22,;27.46,-33.68,;24.99,-30.45,;25.89,-29.2,;27.43,-29.19,;24.98,-27.96,;25.44,-26.49,;23.51,-28.44,;22.18,-27.68,;22.17,-26.14,;20.85,-28.45,;20.85,-29.99,;22.18,-30.77,;23.52,-29.99,;19.51,-30.76,;19.51,-32.3,;18.18,-29.99,)|
Structure:
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