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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50261830
Substrate
n/a
Meas. Tech.
ChEBML_1696472
IC50
6.0±n/a nM
Citation
 Barberis, C; Moorcroft, N; Pribish, J; Tserlin, E; Gross, A; Czekaj, M; Barrague, M; Erdman, P; Majid, T; Batchelor, J; Levit, M; Hebert, A; Shen, L; Moreno-Mazza, S; Wang, A Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification - Part II. Bioorg Med Chem Lett 27:4735-4740 (2017) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50261830
Synonyms:
CHEMBL4105379
Type:
Small organic molecule
Emp. Form.:
C15H15Cl2IN4O
Mol. Mass.:
465.116
SMILES:
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CN4CCC3CC4)c2n1 |(33.51,-30.79,;33.51,-29.25,;32.17,-28.49,;34.84,-28.49,;34.84,-26.94,;36.17,-26.17,;36.17,-24.63,;37.5,-26.94,;38.97,-26.45,;39.44,-24.98,;39.89,-27.69,;41.43,-27.68,;38.98,-28.95,;39.47,-30.41,;40.98,-30.71,;41.46,-32.18,;40.43,-33.33,;38.92,-33.01,;38.44,-31.55,;39.86,-31.35,;39.72,-32.56,;37.51,-28.48,;36.18,-29.26,)|
Structure:
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