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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50261827
Substrate
n/a
Meas. Tech.
ChEBML_1696472
IC50
1.000000±n/a nM
Citation
 Barberis, C; Moorcroft, N; Pribish, J; Tserlin, E; Gross, A; Czekaj, M; Barrague, M; Erdman, P; Majid, T; Batchelor, J; Levit, M; Hebert, A; Shen, L; Moreno-Mazza, S; Wang, A Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification - Part II. Bioorg Med Chem Lett 27:4735-4740 (2017) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50261827
Synonyms:
CHEMBL4070441
Type:
Small organic molecule
Emp. Form.:
C14H15Cl2IN4O
Mol. Mass.:
453.106
SMILES:
NC1CCC(CC1)n1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O |(71.97,-24.68,;71.49,-23.21,;69.98,-22.89,;69.5,-21.44,;70.53,-20.3,;72.04,-20.6,;72.52,-22.06,;70.05,-18.83,;70.95,-17.58,;72.49,-17.57,;70.03,-16.34,;70.5,-14.87,;68.57,-16.82,;67.24,-16.06,;67.23,-14.52,;65.91,-16.83,;65.91,-18.37,;67.24,-19.15,;68.58,-18.37,;64.57,-19.14,;64.57,-20.68,;63.24,-18.37,)|
Structure:
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