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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM50261864
Substrate
n/a
Meas. Tech.
ChEBML_1696473
IC50
6.0±n/a nM
Citation
 Barberis, C; Moorcroft, N; Pribish, J; Tserlin, E; Gross, A; Czekaj, M; Barrague, M; Erdman, P; Majid, T; Batchelor, J; Levit, M; Hebert, A; Shen, L; Moreno-Mazza, S; Wang, A Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification - Part II. Bioorg Med Chem Lett 27:4735-4740 (2017) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM50261864
Synonyms:
CHEMBL4100435
Type:
Small organic molecule
Emp. Form.:
C18H18Cl2N4O
Mol. Mass.:
377.268
SMILES:
NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CC3)n(C3CCCNC3)c2n1
Structure:
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