Reaction Details Report a problem with these data
Target
4-hydroxyphenylpyruvate dioxygenase
Ligand
BDBM50088804
Substrate
n/a
Meas. Tech.
ChEMBL_1698551 (CHEMBL4049533)
IC50
40±n/a nM
Citation
 Santucci, A; Bernardini, G; Braconi, D; Petricci, E; Manetti, F 4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases. J Med Chem 60:4101-4125 (2017) [PubMed]  Article 
Target
Name:
4-hydroxyphenylpyruvate dioxygenase
Synonyms:
HPPD_RAT | Hpd
Type:
PROTEIN
Mol. Mass.:
45113.78
Organism:
Rattus norvegicus
Description:
ChEMBL_545686
Residue:
393
Sequence:
MTTYSNKGPKPERGRFLHFHSVTFWVGNAKQAASFYCNKMGFEPLAYKGLETGSREVVSHVIKQGKIVFVLCSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCEHIVQKARERGAKIVREPWVEEDKFGKVKFAVLQTYGDTTHTLVEKINYTGRFLPGFEAPTYKDTLLPKLPSCNLEIIDHIVGNQPDQEMESASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGRKKSQIQEYVDYNGGAGVQHIALRTEDIITTIRHLRERGMEFLAVPSSYYRLLRENLKTSKIQVKENMDVLEELKILVDYDEKGYLLQIFTKPMQDRPTLFLEVIQRHNHQGFGAGNFNSLFKAFEEEQALRGNLTDLETNGVRSGM
  
Inhibitor
Name:
BDBM50088804
Synonyms:
1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethyl)benzoyl)- | 2-(alpha,alpha,alpha-Trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione | 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione | CHEMBL1337 | NITISINONE
Type:
Small organic molecule
Emp. Form.:
C14H10F3NO5
Mol. Mass.:
329.2281
SMILES:
[O-][N+](=O)c1cc(ccc1C(=O)C1C(=O)CCCC1=O)C(F)(F)F
Structure:
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