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Target
Serine/threonine-protein kinase A-Raf
Ligand
BDBM50264690
Substrate
n/a
Meas. Tech.
ChEMBL_1699091 (CHEMBL4050073)
IC50
43±n/a nM
Citation
 Wang, L; Zhang, Q; Zhu, G; Zhang, Z; Zhi, Y; Zhang, L; Mao, T; Zhou, X; Chen, Y; Lu, T; Tang, W Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance. Eur J Med Chem 130:86-106 (2017) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase A-Raf
Synonyms:
ARAF | ARAF1 | ARAF_HUMAN | PKS | PKS2 | Proto-oncogene A-Raf | Proto-oncogene A-Raf-1 | Proto-oncogene Pks | RAF serine/threonine protein kinase
Type:
Enzyme
Mol. Mass.:
67610.81
Organism:
Homo sapiens (Human)
Description:
P10398
Residue:
606
Sequence:
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP
  
Inhibitor
Name:
BDBM50264690
Synonyms:
CHEMBL4066939
Type:
Small organic molecule
Emp. Form.:
C30H33F3N6O3
Mol. Mass.:
582.6166
SMILES:
CNc1cc(ncn1)C1(CC1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(OC2CCN(C)CC2)c(c1)C(F)(F)F
Structure:
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