Reaction Details Report a problem with these data
Target
Eukaryotic initiation factor 4A-II
Ligand
BDBM50265561
Substrate
n/a
Meas. Tech.
ChEMBL_1700088 (CHEMBL4051070)
IC50
>100000±n/a nM
Citation
 Ito, M; Tanaka, T; Cary, DR; Iwatani-Yoshihara, M; Kamada, Y; Kawamoto, T; Aparicio, S; Nakanishi, A; Imaeda, Y Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors. J Med Chem 60:3335-3351 (2017) [PubMed]  Article 
Target
Name:
Eukaryotic initiation factor 4A-II
Synonyms:
ATP-dependent RNA helicase eIF4A-2 | DDX2B | EIF4A2 | EIF4F | IF4A2_HUMAN | eIF-4A-II | eIF4A-II
Type:
Protein
Mol. Mass.:
46394.69
Organism:
Homo sapiens (Human)
Description:
Q14240
Residue:
407
Sequence:
MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI
  
Inhibitor
Name:
BDBM50265561
Synonyms:
CHEMBL4073833
Type:
Small organic molecule
Emp. Form.:
C29H23BrClN5O2
Mol. Mass.:
588.882
SMILES:
Cc1c(cnn1-c1cccc(c1)C#N)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cc1 |r|
Structure:
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