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Target
Kynurenine 3-monooxygenase
Ligand
BDBM50266003
Substrate
n/a
Meas. Tech.
ChEBML_1700450
IC50
3.2±n/a nM
Citation
 Walker, AL; Ancellin, N; Beaufils, B; Bergeal, M; Binnie, M; Bouillot, A; Clapham, D; Denis, A; Haslam, CP; Holmes, DS; Hutchinson, JP; Liddle, J; McBride, A; Mirguet, O; Mowat, CG; Rowland, P; Tiberghien, N; Trottet, L; Uings, I; Webster, SP; Zheng, X; Mole, DJ Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis. J Med Chem 60:3383-3404 (2017) [PubMed]  Article 
Target
Name:
Kynurenine 3-monooxygenase
Synonyms:
KMO | KMO_HUMAN
Type:
PROTEIN
Mol. Mass.:
55831.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1487479
Residue:
486
Sequence:
MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSHRGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLTAAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKKPRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMPFEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCVLLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQISNLISR
  
Inhibitor
Name:
BDBM50266003
Synonyms:
CHEMBL4091152
Type:
Small organic molecule
Emp. Form.:
C17H15ClN2O4
Mol. Mass.:
346.765
SMILES:
C[C@@H](Oc1cc2onc(CCC(O)=O)c2cc1Cl)c1ccccn1 |r|
Structure:
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