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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM248955
Substrate
n/a
Meas. Tech.
ChEMBL_1701138 (CHEMBL4052120)
Ki
0.110000±n/a nM
Citation
 Wang, X; Kolesnikov, A; Tay, S; Chan, G; Chao, Q; Do, S; Drummond, J; Ebens, AJ; Liu, N; Ly, J; Harstad, E; Hu, H; Moffat, J; Munugalavadla, V; Murray, J; Slaga, D; Tsui, V; Volgraf, M; Wallweber, H; Chang, JH Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. J Med Chem 60:4458-4473 (2017) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM248955
Synonyms:
US9434725, 186
Type:
Small organic molecule
Emp. Form.:
C22H24N8O
Mol. Mass.:
416.479
SMILES:
COc1ccc(nc1N1CCC[C@H](N)C1)-n1ncc2cnc(cc12)-c1cncc(C)n1 |r|
Structure:
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