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Target
D(2) dopamine receptor
Ligand
BDBM50266969
Substrate
n/a
Meas. Tech.
ChEMBL_1701703 (CHEMBL4052936)
Ki
10.0±n/a nM
Citation
 Michino, M; Boateng, CA; Donthamsetti, P; Yano, H; Bakare, OM; Bonifazi, A; Ellenberger, MP; Keck, TM; Kumar, V; Zhu, C; Verma, R; Deschamps, JR; Javitch, JA; Newman, AH; Shi, L Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D J Med Chem 60:580-593 (2017) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50266969
Synonyms:
CHEMBL4093656
Type:
Small organic molecule
Emp. Form.:
C24H26Cl2N4O
Mol. Mass.:
457.395
SMILES:
Clc1cccc(N2CCN(CCCCNC(=O)c3cnc4ccccc4c3)CC2)c1Cl
Structure:
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