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Target
Myeloblastin
Ligand
BDBM50266979
Substrate
n/a
Meas. Tech.
ChEMBL_1701755 (CHEMBL4052988)
Ki
>10000±n/a nM
Citation
 Swedberg, JE; Li, CY; de Veer, SJ; Wang, CK; Craik, DJ Design of Potent and Selective Cathepsin G Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold. J Med Chem 60:658-667 (2017) [PubMed]  Article 
Target
Name:
Myeloblastin
Synonyms:
Leukocyte proteinase 3 | MBN | PRTN3 | PRTN3_HUMAN
Type:
PROTEIN
Mol. Mass.:
27816.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1463425
Residue:
256
Sequence:
MAHRPPSPALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVLLIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVVTFFCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFVIWGCATRLFPDFFTRVALYVDWIRSTLRRVEAKGRP
  
Inhibitor
Name:
BDBM50266979
Synonyms:
CHEMBL4061897
Type:
Small organic molecule
Emp. Form.:
C70H101N15O17S2
Mol. Mass.:
1488.771
SMILES:
CCCCC1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc3ccccc3)NC1=O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N2 |r|
Structure:
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