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Target
Cytochrome P450 11B2, mitochondrial
Ligand
BDBM50011762
Substrate
n/a
Meas. Tech.
ChEMBL_192301 (CHEMBL795454)
IC50
>34000±n/a nM
Citation
 Stanek, J; Alder, A; Bellus, D; Bhatnagar, AS; Häusler, A; Schieweck, K Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones. J Med Chem 34:1329-34 (1991) [PubMed]  Article 
Target
Name:
Cytochrome P450 11B2, mitochondrial
Synonyms:
Aldosterone synthase | C11B2_RAT | CYPXIB2 | Cyp11b-2 | Cyp11b2 | Cytochrome P450 11B | Cytochrome P450 11B2 | Cytochrome P450 11B2, mitochondrial | P450-Aldo-1 | Steroid 11-beta-hydroxylase
Type:
PROTEIN
Mol. Mass.:
58260.64
Organism:
Rattus norvegicus
Description:
ChEMBL_224979
Residue:
510
Sequence:
MGACDNDFIELHSRVTADVWLARPWQCLHRTRALGTTATLAPKTLKPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPRRMHLEPWVAHRELRGLRRGVFLLNGAEWRFNRLKLNPNVLSPKAVQNFVPMVDEVARDFLEALKKKVRQNARGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLNPGSLKFIHALHSMFKSTTQLLFLPRSLTRWTSTQVWKEHFDAWDVISEYANRCIWKVHQELRLGSSQTYSGIVAALITQGALPLDAIKANSMELTAGSVDTTAIPLVMTLFELARNPDVQQALRQETLAAEASIAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILNSDLVLQNYHVPAGTLVLLYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDVQMAYRFVLMPSSSPVLTFRPIS
  
Inhibitor
Name:
BDBM50011762
Synonyms:
(1R,5S)1-(4-Amino-phenyl)-3-cyclohexylmethyl-3-aza-bicyclo[3.1.0]hexane-2,4-dione | (1S,5R)1-(4-Amino-phenyl)-3-cyclohexylmethyl-3-aza-bicyclo[3.1.0]hexane-2,4-dione | 1-(4-Amino-phenyl)-3-cyclohexylmethyl-3-aza-bicyclo[3.1.0]hexane-2,4-dione | CHEMBL281947
Type:
Small organic molecule
Emp. Form.:
C18H22N2O2
Mol. Mass.:
298.3795
SMILES:
Nc1ccc(cc1)C12CC1C(=O)N(CC1CCCCC1)C2=O
Structure:
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