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Target
Metallo-beta-lactamase GIM-1
Ligand
BDBM50267428
Substrate
n/a
Meas. Tech.
ChEMBL_1702771 (CHEMBL4054004)
IC50
23000±n/a nM
Citation
 Skagseth, S; Akhter, S; Paulsen, MH; Muhammad, Z; Lauksund, S; Samuelsen, Ø; Leiros, HS; Bayer, A Metallo-?-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding. Eur J Med Chem 135:159-173 (2017) [PubMed]  Article 
Target
Name:
Metallo-beta-lactamase GIM-1
Synonyms:
GIM-1 | GIM-1 protein | Metallo-beta-lactamase GIM-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27418.35
Organism:
Pseudomonas aeruginosa
Description:
n/a
Residue:
250
Sequence:
MKNVLVFLILLVALPALAQGHKPLEVIKIEDGVYLHTSFKNIEGYGLVDSNGLVVLDNNQAYIIDTPWSEEDTKLLLSWATDRGYQVMASISTHSHEDRTAGIKLLNSKSIPTYTSELTKKLLAREGKPVPTHYFKDDEFTLGNGLIELYYPGAGHTEDNIVAWLPKSKILFGGCLVRSHEWEGLGYVGDASISSWADSIKNIVSKKYPIQMVVPGHGKVGSSDILDHTIDLAESASNKLMQPTAEASAD
  
Inhibitor
Name:
BDBM50267428
Synonyms:
CHEMBL4103833
Type:
Small organic molecule
Emp. Form.:
C10H15O3PS
Mol. Mass.:
246.263
SMILES:
OP(O)(=O)C(CS)CCc1ccccc1
Structure:
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