Reaction Details Report a problem with these data
Target
Thymidylate synthase
Ligand
BDBM50012504
Substrate
n/a
Meas. Tech.
ChEBML_209810
IC50
150±n/a nM
Citation
Marsham, PR; Jackman, AL; Hayter, AJ; Daw, MR; Snowden, JL; O'Connor, BM; Bishop, JA; Calvert, AH; Hughes, LR Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series. J Med Chem 34:2209-18 (1991) [PubMed] Article
More Info.:
Target
Name:
Thymidylate synthase
Synonyms:
TS | TSase | TYSY_MOUSE | Tyms
Type:
PROTEIN
Mol. Mass.:
34957.15
Organism:
Mus musculus
Description:
ChEMBL_1340097
Residue:
307
Sequence:
MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV
Inhibitor
Name:
BDBM50012504
Synonyms:
2-{5-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-1-oxo-1,3-dihydro-isoindol-2-yl}-pentanedioic acid | CHEMBL74059
Type:
Small organic molecule
Emp. Form.:
C26H24N4O6
Mol. Mass.:
488.492
SMILES:
Cc1nc2ccc(CN(CC#C)c3ccc4C(=O)N(Cc4c3)[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1