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Target
Myocilin
Ligand
BDBM7458
Substrate
n/a
Meas. Tech.
ChEMBL_1707012 (CHEMBL4058245)
Kd
41600±n/a nM
Citation
 Srinivasan, B; Tonddast-Navaei, S; Skolnick, J Pocket detection and interaction-weighted ligand-similarity search yields novel high-affinity binders for Myocilin-OLF, a protein implicated in glaucoma. Bioorg Med Chem Lett 27:4133-4139 (2017) [PubMed]  Article 
Target
Name:
Myocilin
Synonyms:
GLC1A | MYOC | MYOC_HUMAN | Myocilin | Myocilin 20 kDa N-terminal fragment | Myocilin 35 kDa N-terminal fragment | Myocilin 55 kDa subunit | Myocilin, C-terminal fragment | Myocilin, N-terminal fragment | TIGR | Trabecular meshwork-induced glucocorticoid response protein
Type:
PROTEIN
Mol. Mass.:
56965.39
Organism:
Homo sapiens
Description:
ChEMBL_117572
Residue:
504
Sequence:
MRFFCARCCSFGPEMPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYTFSVASPNESSCPEQSQAMSVIHNLQRDSSTQRLDLEATKARLSSLESLLHQLTLDQAARPQETQEGLQRELGTLRRERDQLETQTRELETAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGSREVSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGEGDTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKM
  
Inhibitor
Name:
BDBM7458
Synonyms:
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | 5,7-dihydroxy-2-(4-hydroxyphenyl)-chromen-4-one | Apigenin | Apigenin (2) | Apigenin (3) | Apigenin (7) | Apigenin, 13 | CHEMBL28 | Naringenin, 18 | US10278929, Apigenin | US11337935, Compound Apigenin | acs.jmedchem.1c00409_ST.789 | cid_5280443 | jm5b01461, Compound 90
Type:
Small organic molecule
Emp. Form.:
C15H10O5
Mol. Mass.:
270.2369
SMILES:
Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
Structure:
Search PDB for entries with ligand similarity: