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Target
Myocilin
Ligand
BDBM50269650
Substrate
n/a
Meas. Tech.
ChEMBL_1707014 (CHEMBL4058247)
Kd
190000±n/a nM
Citation
 Srinivasan, B; Tonddast-Navaei, S; Skolnick, J Pocket detection and interaction-weighted ligand-similarity search yields novel high-affinity binders for Myocilin-OLF, a protein implicated in glaucoma. Bioorg Med Chem Lett 27:4133-4139 (2017) [PubMed]  Article 
Target
Name:
Myocilin
Synonyms:
GLC1A | MYOC | MYOC_HUMAN | Myocilin | Myocilin 20 kDa N-terminal fragment | Myocilin 35 kDa N-terminal fragment | Myocilin 55 kDa subunit | Myocilin, C-terminal fragment | Myocilin, N-terminal fragment | TIGR | Trabecular meshwork-induced glucocorticoid response protein
Type:
PROTEIN
Mol. Mass.:
56965.39
Organism:
Homo sapiens
Description:
ChEMBL_117572
Residue:
504
Sequence:
MRFFCARCCSFGPEMPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYTFSVASPNESSCPEQSQAMSVIHNLQRDSSTQRLDLEATKARLSSLESLLHQLTLDQAARPQETQEGLQRELGTLRRERDQLETQTRELETAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGSREVSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGEGDTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKM
  
Inhibitor
Name:
BDBM50269650
Synonyms:
CHEMBL4083833
Type:
Small organic molecule
Emp. Form.:
C11H11N7O2
Mol. Mass.:
273.2507
SMILES:
Nc1nc(N)c(\N=N\c2ccc(cc2)C(O)=O)c(N)n1
Structure:
Search PDB for entries with ligand similarity: