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Target
Myocilin
Ligand
BDBM58105
Substrate
n/a
Meas. Tech.
ChEMBL_1707014 (CHEMBL4058247)
Kd
11000±n/a nM
Citation
 Srinivasan, B; Tonddast-Navaei, S; Skolnick, J Pocket detection and interaction-weighted ligand-similarity search yields novel high-affinity binders for Myocilin-OLF, a protein implicated in glaucoma. Bioorg Med Chem Lett 27:4133-4139 (2017) [PubMed]  Article 
Target
Name:
Myocilin
Synonyms:
GLC1A | MYOC | MYOC_HUMAN | Myocilin | Myocilin 20 kDa N-terminal fragment | Myocilin 35 kDa N-terminal fragment | Myocilin 55 kDa subunit | Myocilin, C-terminal fragment | Myocilin, N-terminal fragment | TIGR | Trabecular meshwork-induced glucocorticoid response protein
Type:
PROTEIN
Mol. Mass.:
56965.39
Organism:
Homo sapiens
Description:
ChEMBL_117572
Residue:
504
Sequence:
MRFFCARCCSFGPEMPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYTFSVASPNESSCPEQSQAMSVIHNLQRDSSTQRLDLEATKARLSSLESLLHQLTLDQAARPQETQEGLQRELGTLRRERDQLETQTRELETAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGSREVSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGEGDTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKM
  
Inhibitor
Name:
BDBM58105
Synonyms:
1-(2-methyl-5-propan-2-yl-phenyl)-3-(4-nitrophenyl)urea | 1-(2-methyl-5-propan-2-ylphenyl)-3-(4-nitrophenyl)urea | 1-(5-isopropyl-2-methyl-phenyl)-3-(4-nitrophenyl)urea | MLS000736619 | SMR000528221 | cid_240350
Type:
Small organic molecule
Emp. Form.:
C17H19N3O3
Mol. Mass.:
313.3511
SMILES:
CC(C)c1ccc(C)c(NC(=O)Nc2ccc(cc2)[N+]([O-])=O)c1
Structure:
Search PDB for entries with ligand similarity: