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Target
Myocilin
Ligand
BDBM50235861
Substrate
n/a
Meas. Tech.
ChEMBL_1707014 (CHEMBL4058247)
Kd
0.008±n/a nM
Citation
 Srinivasan, B; Tonddast-Navaei, S; Skolnick, J Pocket detection and interaction-weighted ligand-similarity search yields novel high-affinity binders for Myocilin-OLF, a protein implicated in glaucoma. Bioorg Med Chem Lett 27:4133-4139 (2017) [PubMed]  Article 
Target
Name:
Myocilin
Synonyms:
GLC1A | MYOC | MYOC_HUMAN | Myocilin | Myocilin 20 kDa N-terminal fragment | Myocilin 35 kDa N-terminal fragment | Myocilin 55 kDa subunit | Myocilin, C-terminal fragment | Myocilin, N-terminal fragment | TIGR | Trabecular meshwork-induced glucocorticoid response protein
Type:
PROTEIN
Mol. Mass.:
56965.39
Organism:
Homo sapiens
Description:
ChEMBL_117572
Residue:
504
Sequence:
MRFFCARCCSFGPEMPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYTFSVASPNESSCPEQSQAMSVIHNLQRDSSTQRLDLEATKARLSSLESLLHQLTLDQAARPQETQEGLQRELGTLRRERDQLETQTRELETAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGSREVSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGEGDTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKM
  
Inhibitor
Name:
BDBM50235861
Synonyms:
CHEMBL1597646
Type:
Small organic molecule
Emp. Form.:
C14H14N2O2S
Mol. Mass.:
274.338
SMILES:
COc1cccc(NC(S)=Nc2ccc(O)cc2)c1
Structure:
Search PDB for entries with ligand similarity: