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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM50271098
Substrate
n/a
Meas. Tech.
ChEMBL_1709716 (CHEMBL4119765)
IC50
>200000±n/a nM
Citation
 Wu, J; Kumar, S; Wang, F; Wang, H; Chen, L; Arsenault, P; Mattern, M; Weinstock, J Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies. J Med Chem 61:422-443 (2018) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCHL3 | UCHL3_HUMAN | Ubiquitin C-terminal Hydrolase L3 (UCH-L3) | Ubiquitin thioesterase L3
Type:
Hydrolase; protease
Mol. Mass.:
26168.69
Organism:
Homo sapiens (Human)
Description:
Human recombinant UCH-L3 was purchased from Boston Biochem, Inc.(Cambridge, MA).
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
  
Inhibitor
Name:
BDBM50271098
Synonyms:
CHEMBL4129140
Type:
Small organic molecule
Emp. Form.:
C20H16BrCl2NO3
Mol. Mass.:
469.156
SMILES:
CC(=O)C1=C(O)C(=O)N(CCc2ccc(Cl)c(Cl)c2)C1c1ccc(Br)cc1 |c:3|
Structure:
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