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Target
Ephrin type-A receptor 7
Ligand
BDBM50271212
Substrate
n/a
Meas. Tech.
ChEMBL_1710135 (CHEMBL4120184)
IC50
665±n/a nM
Citation
 Patel, S; Meilandt, WJ; Erickson, RI; Chen, J; Deshmukh, G; Estrada, AA; Fuji, RN; Gibbons, P; Gustafson, A; Harris, SF; Imperio, J; Liu, W; Liu, X; Liu, Y; Lyssikatos, JP; Ma, C; Yin, J; Lewcock, JW; Siu, M Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem 60:8083-8102 (2017) [PubMed]  Article 
Target
Name:
Ephrin type-A receptor 7
Synonyms:
2.7.10.1 | EHK-3 | EHK3 | EK11 | EPH homology kinase 3 | EPH-like kinase 11 | EPHA7 | EPHA7_HUMAN | Ephrin receptor | HEK11 | Tyrosine Kinase EPHA6 | Tyrosine Kinase EPHA7
Type:
n/a
Mol. Mass.:
112085.32
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
998
Sequence:
MVFQTRYPSWIILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWISKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKKGFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEEEAENAPRMHCSAEGEWLVPIGKCICKAGYQQKGDTCEPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGRNDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAAPSQVSGVMKERVLQRSVELSWQEPEHPNGVITEYEIKYYEKDQRERTYSTVKTKSTSASINNLKPGTVYVFQIRAFTAAGYGNYSPRLDVATLEEATGKMFEATAVSSEQNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFHFKFPGTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIRNPNSLKTPLGTCSRPISPLLDQNTPDFTTFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTIEDVMSLGITLVGHQKKIMSSIQTMRAQMLHLHGTGIQV
  
Inhibitor
Name:
BDBM50271212
Synonyms:
CHEMBL3715238
Type:
Small organic molecule
Emp. Form.:
C21H24F3N5O
Mol. Mass.:
419.4434
SMILES:
[H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC1CC1)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r|
Structure:
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