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Target
Serine/threonine-protein kinase ULK1
Ligand
BDBM379177
Substrate
n/a
Meas. Tech.
ChEMBL_1711143 (CHEMBL4121192)
IC50
108±n/a nM
Citation
 Zhang, L; Ouyang, L; Guo, Y; Zhang, J; Liu, B UNC-51-like Kinase 1: From an Autophagic Initiator to Multifunctional Drug Target. J Med Chem 61:6491-6500 (2018) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase ULK1
Synonyms:
ATG1 | Autophagy-related protein 1 homolog | KIAA0722 | ULK1 | ULK1_HUMAN | Unc-51-like kinase 1 | hATG1
Type:
PROTEIN
Mol. Mass.:
112661.80
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1510275
Residue:
1050
Sequence:
MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSGSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPPAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTLPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESLQEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGPRTRMFSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGFAEQLVLYLKVAELLSSGLQSAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRFFLDKQRLLDRIHSITAERLIFSHAVQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHMLSDQADIENVTKCKLCIERRLSALLTGICA
  
Inhibitor
Name:
BDBM379177
Synonyms:
2-(5-Bromo-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-yloxy)-N-methylbenzamide | US10266549, Example 171a | US10266549, Example 88 | US10774092, Example 171a
Type:
Small organic molecule
Emp. Form.:
C21H21BrN4O5
Mol. Mass.:
489.319
SMILES:
CNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br
Structure:
Search PDB for entries with ligand similarity: