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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50014014
Substrate
n/a
Meas. Tech.
ChEBML_157719
pH
6.4±n/a
Ki
70±n/a nM
Comments
extracted
Citation
 Rich, DH; Green, J; Toth, MV; Marshall, GR; Kent, SB Hydroxyethylamine analogues of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease. J Med Chem 33:1285-8 (1990) [PubMed]  Article 
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM50014014
Synonyms:
2-{2-[3-(Acetyl-tert-butyl-amino)-4-cyclohexyl-2-hydroxy-butylamino]-3-methyl-butyrylamino}-3-methyl-pentanoic acid (pyridin-2-ylmethyl)-amide | CHEMBL3143738
Type:
Small organic molecule
Emp. Form.:
C33H57N5O4
Mol. Mass.:
587.8368
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@@H](NC[C@H](O)[C@H](CC1CCCCC1)N(C(C)=O)C(C)(C)C)C(C)C)C(=O)NCc1ccccn1 |r|
Structure:
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