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Target
Renin
Ligand
BDBM50273160
Substrate
n/a
Meas. Tech.
ChEMBL_1712839 (CHEMBL4122888)
IC50
310±n/a nM
Citation
 Tokuhara, H; Imaeda, Y; Fukase, Y; Iwanaga, K; Taya, N; Watanabe, K; Kanagawa, R; Matsuda, K; Kajimoto, Y; Kusumoto, K; Kondo, M; Snell, G; Behnke, CA; Kuroita, T Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile. Bioorg Med Chem 26:3261-3286 (2018) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
RENI_RAT | Ren | Ren1
Type:
PROTEIN
Mol. Mass.:
44272.67
Organism:
Rattus norvegicus
Description:
ChEMBL_222765
Residue:
402
Sequence:
MGGRRMPLWALLLLWTSCSFSLPTDTASFGRILLKKMPSVREILEERGVDMTRISAEWGEFIKKSSFTNVTSPVVLTNYLDTQYYGEIGIGTPSQTFKVIFDTGSANLWVPSTKCGPLYTACEIHNLYDSSESSSYMENGTEFTIHYGSGKVKGFLSQDVVTVGGIIVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVDGVIPVFDHILSQRVLKEEVFSVYYSRESHLLGGEVVLGGSDPQHYQGNFHYVSISKAGSWQITMKGVSVGPATLLCEEGCMAVVDTGTSYISGPTSSLQLIMQALGVKEKRANNYVVNCSQVPTLPDISFYLGGRTYTLSNMDYVQKNPFRNDDLCILALQGLDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR
  
Inhibitor
Name:
BDBM50273160
Synonyms:
IMARIKIREN
Type:
Small organic molecule
Emp. Form.:
C27H41N5O4
Mol. Mass.:
499.6455
SMILES:
COCCCCn1c(nc2ccccc12)C(=O)N(CC(C)C)[C@@H]1CNC[C@@H](C1)C(=O)N1CCOCC1 |r|
Structure:
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