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Target
Renin
Ligand
BDBM50014134
Substrate
n/a
Meas. Tech.
ChEBML_196290
IC50
390±n/a nM
Citation
 Dutta, AS; Gormley, JJ; McLachlan, PF; Major, JS Inhibitors of human renin. Cyclic peptide analogues containing a D-Phe-Lys-D-Trp sequence. J Med Chem 33:2560-8 (1990) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
RENI_RAT | Ren | Ren1
Type:
PROTEIN
Mol. Mass.:
44272.67
Organism:
Rattus norvegicus
Description:
ChEMBL_222765
Residue:
402
Sequence:
MGGRRMPLWALLLLWTSCSFSLPTDTASFGRILLKKMPSVREILEERGVDMTRISAEWGEFIKKSSFTNVTSPVVLTNYLDTQYYGEIGIGTPSQTFKVIFDTGSANLWVPSTKCGPLYTACEIHNLYDSSESSSYMENGTEFTIHYGSGKVKGFLSQDVVTVGGIIVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVDGVIPVFDHILSQRVLKEEVFSVYYSRESHLLGGEVVLGGSDPQHYQGNFHYVSISKAGSWQITMKGVSVGPATLLCEEGCMAVVDTGTSYISGPTSSLQLIMQALGVKEKRANNYVVNCSQVPTLPDISFYLGGRTYTLSNMDYVQKNPFRNDDLCILALQGLDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR
  
Inhibitor
Name:
BDBM50014134
Synonyms:
6-Amino-2-(3-benzyl-2,5,9-trioxo-6-phenyl-[1,4]diazonan-1-yl)-hexanoic acid [2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide | CHEMBL86410
Type:
Small organic molecule
Emp. Form.:
C42H52N6O5
Mol. Mass.:
720.8995
SMILES:
CC(C)CCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)N1C(=O)CCC(c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C1=O
Structure:
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