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Target
Histone deacetylase 11
Ligand
BDBM50273553
Substrate
n/a
Meas. Tech.
ChEMBL_1713030 (CHEMBL4123079)
IC50
2.0±n/a nM
Citation
 Martin, MW; Lee, JY; Lancia, DR; Ng, PY; Han, B; Thomason, JR; Lynes, MS; Marshall, CG; Conti, C; Collis, A; Morales, MA; Doshi, K; Rudnitskaya, A; Yao, L; Zheng, X Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11. Bioorg Med Chem Lett 28:2143-2147 (2018) [PubMed]  Article 
Target
Name:
Histone deacetylase 11
Synonyms:
HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
39187.66
Organism:
Homo sapiens (Human)
Description:
Q96DB2
Residue:
347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
  
Inhibitor
Name:
BDBM50273553
Synonyms:
CHEMBL4127020 | US10508088, ID HDTK028 | US11535607, Example 17-1
Type:
Small organic molecule
Emp. Form.:
C19H17F3N4O2
Mol. Mass.:
390.3591
SMILES:
CC1(C)N(Cc2c1cccc2C(=O)NO)c1nc2ccc(cc2[nH]1)C(F)(F)F
Structure:
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