Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50275599
Substrate
n/a
Meas. Tech.
ChEMBL_1714792 (CHEMBL4124841)
IC50
5.3±n/a nM
Citation
 Varano, F; Catarzi, D; Falsini, M; Vincenzi, F; Pasquini, S; Varani, K; Colotta, V Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A Bioorg Med Chem 26:3688-3695 (2018) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50275599
Synonyms:
CHEMBL4127213
Type:
Small organic molecule
Emp. Form.:
C19H17N5OS
Mol. Mass.:
363.436
SMILES:
COc1ccccc1CNc1nc(N)c2nc(sc2n1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: