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Target
Plasmepsin IV [1-448]
Ligand
BDBM50276301
Substrate
n/a
Meas. Tech.
ChEMBL_1715579 (CHEMBL4125628)
Ki
3345±n/a nM
Citation
 Kumar Singh, A; Rajendran, V; Singh, S; Kumar, P; Kumar, Y; Singh, A; Miller, W; Potemkin, V; Poonam, na; Grishina, M; Gupta, N; Kempaiah, P; Durvasula, R; Singh, BK; Dunn, BM; Rathi, B Antiplasmodial activity of hydroxyethylamine analogs: Synthesis, biological activity and structure activity relationship of plasmepsin inhibitors. Bioorg Med Chem 26:3837-3844 (2018) [PubMed]  Article 
Target
Name:
Plasmepsin IV [1-448]
Synonyms:
PLM4_PLAF7 | PMIV | Plasmepsin 4 (PM-IV)
Type:
Enzyme
Mol. Mass.:
50925.00
Organism:
Plasmodium falciparum
Description:
Q8IM16[1-448]
Residue:
448
Sequence:
MALTVKEEEFSNTLIKNASAFDRLKLGNLKNLKIQKKLQFLYLILFVLITGVFFFFLIGNFYSHRKLYQVIKNTKHTTIGFKIDRPHDKVLSSVLKNKLSTYVKESFKFFKSGYAQKGYLGSENDSIELDDVANLMFYGEGQIGTNKQPFMFIFDTGSANLWVPSVNCDSIGCSTKHLYDASASKSYEKDGTKVEISYGSGTVRGYFSKDVISLGDLSLPYKFIEVTDADDLEPIYSGSEFDGILGLGWKDLSIGSIDPVVVELKKQNKIDNALFTFYLPVHDKHVGYLTIGGIESDFYEGPLTYEKLNHDLYWQIDLDIHFGKYVMQKANAVVDSGTSTITAPTSFLNKFFRDMNVIKVPFLPLYVTTCDNDDLPTLEFHSRNNKYTLEPEFYMDPLSDIDPALCMLYILPVDIDDNTFILGDPFMRKYFTVFDYEKESVGFAVAKN
  
Inhibitor
Name:
BDBM50276301
Synonyms:
CHEMBL4128581
Type:
Small organic molecule
Emp. Form.:
C46H50N6O8
Mol. Mass.:
814.9246
SMILES:
Cc1ccc2C(=O)N(CC(=O)N[C@H](Cc3ccccc3)[C@@H](O)CN3CCN(C[C@@H](O)[C@H](Cc4ccccc4)NC(=O)CN4C(=O)c5ccc(C)cc5C4=O)CC3)C(=O)c2c1 |r|
Structure:
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