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Target
Ectonucleoside triphosphate diphosphohydrolase 2
Ligand
BDBM50276782
Substrate
n/a
Meas. Tech.
ChEBML_1716385
IC50
>300000±n/a nM
Citation
 Kuhrt, D; Ejaz, SA; Afzal, S; Khan, SU; Lecka, J; Sévigny, J; Ehlers, P; Spannenberg, A; Iqbal, J; Langer, P Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors. Eur J Med Chem 138:816-829 (2017) [PubMed]  Article 
Target
Name:
Ectonucleoside triphosphate diphosphohydrolase 2
Synonyms:
CD39L1 | ENTP2_HUMAN | ENTPD2
Type:
PROTEIN
Mol. Mass.:
53675.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453714
Residue:
495
Sequence:
MAGKVRSLLPPLLLAAAGLAGLLLLCVPTRDVREPPALKYGIVLDAGSSHTSMFIYKWPADKENDTGIVGQHSSCDVPGGGISSYADNPSGASQSLVGCLEQALQDVPKERHAGTPLYLGATAGMRLLNLTNPEASTSVLMAVTHTLTQYPFDFRGARILSGQEEGVFGWVTANYLLENFIKYGWVGRWFRPRKGTLGAMDLGGASTQITFETTSPAEDRASEVQLHLYGQHYRVYTHSFLCYGRDQVLQRLLASALQTHGFHPCWPRGFSTQVLLGDVYQSPCTMAQRPQNFNSSARVSLSGSSDPHLCRDLVSGLFSFSSCPFSRCSFNGVFQPPVAGNFVAFSAFFYTVDFLRTSMGLPVATLQQLEAAAVNVCNQTWAQLQARVPGQRARLADYCAGAMFVQQLLSRGYGFDERAFGGVIFQKKAADTAVGWALGYMLNLTNLIPADPPGLRKGTDFSSWVVLLLLFASALLAALVLLLRQVHSAKLPSTI
  
Inhibitor
Name:
BDBM50276782
Synonyms:
CHEMBL4165654
Type:
Small organic molecule
Emp. Form.:
C14H6BrClF3NS
Mol. Mass.:
392.621
SMILES:
FC(F)(F)c1nc2c(cccc2c(Cl)c1Br)-c1ccsc1
Structure:
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