Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50276840
Substrate
n/a
Meas. Tech.
ChEMBL_1716852 (CHEMBL4131852)
EC50
1.1±n/a nM
Citation
 Teleb, M; Kuppast, B; Spyridaki, K; Liapakis, G; Fahmy, H Synthesis of 2-imino and 2-hydrazono thiazolo[4,5-d]pyrimidines as corticotropin releasing factor (CRF) antagonists. Eur J Med Chem 138:900-908 (2017) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50276840
Synonyms:
CHEMBL4160471
Type:
Small organic molecule
Emp. Form.:
C21H29N5S
Mol. Mass.:
383.553
SMILES:
CCCCN(CC)c1nc(C)nc2n(-c3c(C)cc(C)cc3C)c(=N)sc12 |(33.93,-2.38,;33.94,-3.92,;32.61,-4.69,;32.61,-6.23,;31.28,-7.01,;29.95,-6.24,;29.94,-4.7,;31.29,-8.55,;29.96,-9.32,;29.95,-10.86,;28.62,-11.63,;31.29,-11.63,;32.63,-10.86,;34.11,-11.33,;34.1,-12.87,;32.75,-13.63,;31.43,-12.85,;32.74,-15.17,;34.07,-15.95,;34.06,-17.49,;35.41,-15.18,;35.42,-13.64,;36.76,-12.88,;35.01,-10.07,;36.55,-10.06,;34.09,-8.82,;32.62,-9.31,)|
Structure:
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