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Target
Protein-glutamine gamma-glutamyltransferase 2
Ligand
BDBM50277162
Substrate
n/a
Meas. Tech.
ChEBML_1717644
IC50
>2000000±n/a nM
Citation
 De Simone, A; Bartolini, M; Baschieri, A; Apperley, KYP; Chen, HH; Guardigni, M; Montanari, S; Kobrlova, T; Soukup, O; Valgimigli, L; Andrisano, V; Keillor, JW; Basso, M; Milelli, A Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease. Eur J Med Chem 139:378-389 (2017) [PubMed]  Article 
Target
Name:
Protein-glutamine gamma-glutamyltransferase 2
Synonyms:
Tissue transglutaminase (TG2) | Transglutaminase 2 (TGM2) | Protein-glutamine gamma-glutamyltransferase | Tissue transglutaminase | Transglutaminase C | Transglutaminase-2 | TGM2_HUMAN | TGM2 | Protein-glutamine gamma-glutamyltransferase 2 (TG2)
Type:
Protein
Mol. Mass.:
77309.30
Organism:
Human
Description:
P21980
Residue:
687
Sequence:
MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFSVVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVGQSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEKSVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQKRKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVIIGPA
  
Inhibitor
Name:
BDBM50277162
Synonyms:
CHEMBL4174015
Type:
Small organic molecule
Emp. Form.:
C14H11NO2
Mol. Mass.:
225.25
SMILES:
Oc1ccc(\C=C\C(=O)c2cccnc2)cc1
Structure:
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