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Target
C-C chemokine receptor type 4
Ligand
BDBM50278724
Substrate
n/a
Meas. Tech.
ChEMBL_1719304 (CHEMBL4134304)
IC50
10.0±n/a nM
Citation
 Kindon, N; Andrews, G; Baxter, A; Cheshire, D; Hemsley, P; Johnson, T; Liu, YZ; McGinnity, D; McHale, M; Mete, A; Reuberson, J; Roberts, B; Steele, J; Teobald, B; Unitt, J; Vaughan, D; Walters, I; Stocks, MJ Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists. ACS Med Chem Lett 8:981-986 (2017) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 4
Synonyms:
C-C CKR-4 | CC-CKR-4 | CCR-4 | CCR4_MOUSE | CD_antigen=CD194 | Ccr4 | Cmkbr4
Type:
PROTEIN
Mol. Mass.:
41410.76
Organism:
Mus musculus
Description:
ChEMBL_512157
Residue:
360
Sequence:
MNATEVTDTTQDETVYNSYYFYESMPKPCTKEGIKAFGEVFLPPLYSLVFLLGLFGNSVVVLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQWVFGLGLCKIVSWMYLVGFYSGIFFIMLMSIDRYLAIVHAVFSLKARTLTYGVITSLITWSVAVFASLPGLLFSTCYTEHNHTYCKTQYSVNSTTWKVLSSLEINVLGLLIPLGIMLFCYSMIIRTLQHCKNEKKNRAVRMIFAVVVLFLGFWTPYNVVLFLETLVELEVLQDCTLERYLDYAIQATETLAFIHCCLNPVIYFFLGEKFRKYITQLFRTCRGPLVLCKHCDFLQVYSADMSSSSYTQSTVDHDFRDAL
  
Inhibitor
Name:
BDBM50278724
Synonyms:
CHEMBL4169247
Type:
Small organic molecule
Emp. Form.:
C11H9Cl2N3O3S
Mol. Mass.:
334.178
SMILES:
COc1nccnc1NS(=O)(=O)c1cccc(Cl)c1Cl
Structure:
Search PDB for entries with ligand similarity: