Reaction Details Report a problem with these data
Target
Cystathionine gamma-lyase
Ligand
BDBM50280040
Substrate
n/a
Meas. Tech.
ChEMBL_1721611 (CHEMBL4136611)
IC50
1100±n/a nM
Citation
 Bhattacharjee, A; Sinha, A; Ratia, K; Yin, L; Delgado-Rivera, L; Petukhov, PA; Thatcher, GRJ; Wardrop, DJ 2-Arylidene Hydrazinecarbodithioates as Potent, Selective Inhibitors of Cystathionine ?-Lyase (CSE). ACS Med Chem Lett 8:1241-1245 (2017) [PubMed]  Article 
Target
Name:
Cystathionine gamma-lyase
Synonyms:
CGL_HUMAN | CTH | Cystathionine gamma-lyase (CSE) | Cysteine-protein sulfhydrase | Gamma-cystathionase
Type:
Protein
Mol. Mass.:
44509.52
Organism:
Homo sapiens (Human)
Description:
P32929
Residue:
405
Sequence:
MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS
  
Inhibitor
Name:
BDBM50280040
Synonyms:
CHEMBL1619821
Type:
Small organic molecule
Emp. Form.:
C6H12N2O3
Mol. Mass.:
160.1711
SMILES:
NCCO\C=C\[C@H](N)C(O)=O
Structure:
Search PDB for entries with ligand similarity: