Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50018078
Substrate
n/a
Meas. Tech.
ChEMBL_1722785 (CHEMBL4137785)
Ki
63±n/a nM
Citation
 Bautista-Aguilera, ÓM; Budni, J; Mina, F; Medeiros, EB; Deuther-Conrad, W; Entrena, JM; Moraleda, I; Iriepa, I; López-Muñoz, F; Marco-Contelles, J Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile. J Med Chem 61:6937-6943 (2018) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM50018078
Synonyms:
2-(4-Phenyl-piperidin-1-yl)-cyclohexanol | 2-(4-Phenyl-piperidin-1-yl)-cyclohexanol([3H]-(-)Vesamicol) | CHEMBL20943 | US10421722, Compound Vesamicolb | V-100
Type:
Small organic molecule
Emp. Form.:
C17H25NO
Mol. Mass.:
259.3865
SMILES:
OC1CCCCC1N1CCC(CC1)c1ccccc1
Structure:
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