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Target
Chymotrypsin-like elastase family member 1/2A
Ligand
BDBM50015856
Substrate
n/a
Meas. Tech.
ChEMBL_152340 (CHEMBL758721)
IC50
400±n/a nM
Citation
 Doherty, JB; Ashe, BM; Barker, PL; Blacklock, TJ; Butcher, JW; Chandler, GO; Dahlgren, ME; Davies, P; Dorn, CP; Finke, PE Inhibition of human leukocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-butyl esters. J Med Chem 33:2513-21 (1990) [PubMed]  Article 
Target
Name:
Chymotrypsin-like elastase family member 1/2A
Synonyms:
Pancreatic elastase
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 152345
Components:
This complex has 2 components.
Component 1
Name:
Chymotrypsin-like elastase family member 1
Synonyms:
CELA1 | CELA1_PIG | ELA1 | Elastase | Elastase 1 | Elastase-1 | Pancreatic elastase
Type:
Enzyme
Mol. Mass.:
28827.71
Organism:
Sus scrofa (Pig)
Description:
P00772
Residue:
266
Sequence:
MLRLLVVASLVLYGHSTQDFPETNARVVGGTEAQRNSWPSQISLQYRSGSSWAHTCGGTLIRQNWVMTAAHCVDRELTFRVVVGEHNLNQNDGTEQYVGVQKIVVHPYWNTDDVAAGYDIALLRLAQSVTLNSYVQLGVLPRAGTILANNSPCYITGWGLTRTNGQLAQTLQQAYLPTVDYAICSSSSYWGSTVKNSMVCAGGDGVRSGCQGDSGGPLHCLVNGQYAVHGVTSFVSRLGCNVTRKPTVFTRVSAYISWINNVIASN
  
Component 2
Name:
Chymotrypsin-like elastase family member 2A
Synonyms:
CEL2A_PIG | CELA2A | ELA2 | ELA2A | Elastase 2A | Elastase-2 | Elastase-2A | Pancreatic elastase
Type:
PROTEIN
Mol. Mass.:
28705.23
Organism:
Sus scrofa
Description:
ChEMBL_156951
Residue:
269
Sequence:
MIRALLLSTLVAGALSCGLPANLPQLPRVVGGEDARPNSWPWQVSLQYDSSGQWRHTCGGTLVDQSWVLTAAHCISSSRTYRVVLGRHSLSTNEPGSLAVKVSKLVVHQDWNSNQLSNGNDIALLKLASPVSLTDKIQLGCLPAAGTILPNNYVCYVTGWGRLQTNGASPDILQQGQLLVVDYATCSKPGWWGSTVKTNMICAGGDGIISSCNGDSGGPLNCQGANGQWQVHGIVSFGSSLGCNYYHKPSVFTRVSNYIDWINSVIANN
  
Inhibitor
Name:
BDBM50015856
Synonyms:
3-Acetoxymethyl-7-formyloxy-5,5,8-trioxo-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester | CHEMBL313754
Type:
Small organic molecule
Emp. Form.:
C15H19NO9S
Mol. Mass.:
389.378
SMILES:
CC(=O)OCC1=C(N2[C@@H]([C@@H](OC=O)C2=O)S(=O)(=O)C1)C(=O)OC(C)(C)C |t:5|
Structure:
Search PDB for entries with ligand similarity: