Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50016023
Substrate
n/a
Meas. Tech.
ChEBML_192730
IC50
15000±n/a nM
Citation
Kaltenbronn, JS; Hudspeth, JP; Lunney, EA; Michniewicz, BM; Nicolaides, ED; Repine, JT; RoarK, WH; Stier, MA; Tinney, FJ; Woo, PK Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites. J Med Chem 33:838-45 (1990) [PubMed] Article
More Info.:
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Inhibitor
Name:
BDBM50016023
Synonyms:
3-Hydroxy-6-methyl-4-{3-methyl-2-[3-methyl-2-(3-methyl-butyrylamino)-butylamino]-butyrylamino}-heptanoic acid (1-benzylcarbamoyl-3-methyl-butyl)-amide : (0.2 acetic acid) | CHEMBL351622
Type:
Small organic molecule
Emp. Form.:
C36H63N5O5
Mol. Mass.:
645.9159
SMILES:
CC(C)C[C@H](NC(=O)[C@@H](NC[C@@H](NC(=O)CC(C)C)C(C)C)C(C)C)C(O)CC(=O)N[C@@H](CC(C)C)C(=O)NCc1ccccc1